How does Heparan Sulfate and COVID-19 Work?: An Overview

Globally, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) had infected over 3 million individuals and claimed many lives producing a global epidemic that necessitates rapid development of therapeutic solutions. The ideal technique for quickly deploying well-characterized medicines against novel infections is known as drug repurposing. Several repurposable are currently being tested to see if they may be used treat COVID-19. Heparin, which commonly utilized reduce thrombotic events associated with COVID-19-induced disease, one such promising drug. Heparansulphate prevalently expressed in mammalian tissues. CoV-2 requires helping cofactor heparansulphate (HS) on cell surface: knocking down genes related HS formation or treating cells an mimic both prevent spike-mediated viral entrance. Heparin/HS binds directly spike promotes entrance by facilitating attachment spike-bearing particles surface. As documented surface-bound heparansulphate, heparin binding open conformation structurally supports state enhance ACE2 binding. Thus, could potentially utilised SARS-CoV-2 transmission, based available datas also consumption during cellular play role COVID-19 infection. Furthermore, this study provides findings mechanism(s) slow progression infection.
 Keywords: COVID-19, HeparanSulphate, Spike Protiens